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At least we know that many factorsincluding duration, frequency, and location of the Ca2+ signal, as well as interactions with other cellular componentsaffect the downstream response (McAinsh et al., 1997

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Detailed molecular structure Comparison with native IGF-1 Native human IGF-1 is a 70-amino-acid peptide with three intramolecular disulfide bridges (Cys6-Cys48, Cys47-Cys52, Cys18-Cys61) stabilizing its folding into four domains (B, C, A, D) analogous to those of proinsulin

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